Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers—A Pilot Study

Because miRNAs regulate the expression of a wide range of genes, including those involved in clozapine's efficacy and safety, these findings underscore the need for further studies integrating pharmacoepigenetic and pharmacogenetic biomarkers. Our preliminary findings suggest that specific miRNAs could be candidate biomarkers associated with clozapine response in TRS, although these results require validation in larger and controlled studies.