Novel histone deacetylase inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis

20250 citationsJournal Articlehybrid Open Access

Authors

Livia Stanger · University of Michigan

Pooja Yalavarthi · University of Michigan

Reheman Adili · University of Michigan

Devin Gilmore · University of Michigan

Timothy N. Hoang · University of Michigan

A. Dean Campbell · University of Michigan

Paul Krenik ·

Abstract

CS014 represents a novel HDAC inhibitor with the potential for reducing hepatotoxicity while maintaining the benefit of preventing injury-induced clotting without increased bleeding diathesis.

Topics & Keywords

Histone Deacetylase Inhibitors Research Platelet Disorders and Treatments Hemophilia Treatment and Research

Publication Details

Published in: Journal of Thrombosis and Haemostasis

Volume 24, Issue 3, pp. 1042-1055

DOI: 10.1016/j.jtha.2025.11.011

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Novel histone deacetylase inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis

Authors

Abstract

Topics & Keywords

Publication Details