Respiratory and Antinociceptive Effects of Nociceptin Receptor–µ-Opioid Receptor Agonist Cebranopadol versus Full Opioid Receptor Agonist Oxycodone: A Comparison in Healthy Volunteers

20250 citationsJournal Articlegreen Open Access

Authors

Simone Jansen · Leiden University Medical Center

Erik Olofsen · Leiden University Medical Center

Laurence Moss · Leiden University Medical Center

Joseph C. Grieco · PharmaSeq (United States)

Marc L. Lesnick · PharmaSeq (United States)

J. V. Hackworth · PharmaSeq (United States)

Monique van Velzen

Abstract

The primary endpoint showed separation between the respiratory effects of cebranopadol and oxycodone, with 25% less respiratory depression at equianalgesia, as observed in the pharmacokinetic/pharmacodynamic analysis.

Topics & Keywords

Pain Management and Opioid Use Neuropeptides and Animal Physiology Pain Mechanisms and Treatments

Publication Details

Published in: Anesthesiology

Volume 144, Issue 4, pp. 913-925

DOI: 10.1097/aln.0000000000005894

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Respiratory and Antinociceptive Effects of Nociceptin Receptor–µ-Opioid Receptor Agonist Cebranopadol versus Full Opioid Receptor Agonist Oxycodone: A Comparison in Healthy Volunteers

Authors

Abstract

Topics & Keywords

Publication Details