A predictive model for life-threatening fluoropyrimidine toxicity based on <i>DPYD</i> sequencing in colorectal cancer

20250 citationsJournal Article

Authors

Valérie Boige · Inserm

Estelle Menoret · Inserm

Gwénaël Le Teuff · Inserm

Jean-Christophe Boyer · Centre Hospitalier Universitaire de Nîmes

Nathalie Cozic · Inserm

Jean‐Pierre Desvignes · Inserm

Julien Taı̈eb · Centre National de la Recherche Scientifique

Abstract

DPYD sequencing identified additional relevant variants and improved the sensitivity of DPYD testing. An online calculator (https://fluoropyrimidine-toxicity-predictor.gustaveroussy.fr/) is provided to estimate the individual probability of developing life-threatening toxicity, based on clinical covariates and extended DPYD genotype.

Topics & Keywords

Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer Lung Cancer Treatments and Mutations

Publication Details

Published in: JNCI Journal of the National Cancer Institute

DOI: 10.1093/jnci/djaf357

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A predictive model for life-threatening fluoropyrimidine toxicity based on <i>DPYD</i> sequencing in colorectal cancer

Authors

Abstract

Topics & Keywords

Publication Details