Burden and trends of cardiovascular diseases attributable to high LDL-C in China, 1990–2021: an age-period-cohort analysis with projectioans to 2050

The burden of CVD caused by high LDL-C in China increased overall from 1990 to 2021. The stratified results by gender indicated that the ASMR and ASDR of men were higher than those of women. Stratification by age showed that the burden was the greatest among people over 70 years old. This was mainly due to population growth, aging, and risk factors. The prediction shows that the disease burden will continue to rise until 2050, and men will remain a high-risk group. Given the continuous trend of population aging, it is necessary to consider various lipid-lowering strategies and the effective allocation of medical resources in the future to reduce the disease burden related to CVD caused by high LDL-C.