Uncovering the Red Flags: A Cross-Sectional Retrospective Case–Control Study on Predictors of Early-Onset Colorectal Cancer in a Multistate Community Health System

There is a need for risk stratification models that simultaneously consider symptoms, medical history, and sociodemographic characteristics. This study identified a set of risk factors that can be used to recommend early screening to symptomatic and asymptomatic patients below the age of 45, even among those without high-risk familial background.