Predictors of vertebral fractures in patients with severe osteoporosis: a sub-analysis of the Japanese Osteoporosis Intervention Trial-05 (JOINT-05)

Beyond established risk factors such as pre-existing fractures, this study identified the allocation of osteoporosis treatment, low serum triglyceride levels, and the intensity of low back pain as independent predictors of new VFs in high-risk elderly women. Thus, clinical strategies to prevent subsequent fractures should include optimizing pharmacological treatment (e.g., sequential therapy with teriparatide), considering lipid status, and implementing effective, multimodal pain management.