Ketamine, Etomidate, and Mortality in Emergency Department Intubations

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Authors

Ian Ward Abdalla Maia · Mayo Clinic

Sérgio Renato da Rosa Decker · Beth Israel Deaconess Medical Center

Lucas Oliveira J. e Silva · Mayo Clinic

Rafael von Hellmann · Monash Health

Júlio César Garcia de Alencar · Universidade Sagrado Coração

Ludhmila Abrahão Hajjar · Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Jóni Costa Carvalho

Abstract

In this cohort study of critically ill adults undergoing RSI, etomidate use was associated with higher in-hospital mortality at 7 and 28 days compared with ketamine. These findings highlight the need for definitive randomized clinical trials to compare both agents.

Topics & Keywords

Anesthesia and Sedative Agents Adrenal Hormones and Disorders Treatment of Major Depression

Publication Details

Published in: JAMA Network Open

Volume 8, Issue 12, pp. e2548060-e2548060

DOI: 10.1001/jamanetworkopen.2025.48060

Field-Weighted Citation Impact: 4.50

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Ketamine, Etomidate, and Mortality in Emergency Department Intubations

Authors

Abstract

Topics & Keywords

Publication Details