Varied human milk oligosaccharides in human milk from mothers treated with antidepressants and anti-inflammatories

In human milk, maternal treatment with antidepressants and anti-inflammatories was associated with higher levels of several fucosylated oligosaccharides, particularly among antidepressant users, a trend toward lower sialylated and non-fucosylated, non-sialylated oligosaccharide levels, and lower total human milk oligosaccharide concentrations among secretors. It is unknown whether these associations are causal, and the overall clinical implications of these findings for the breastfed infant are not clear. Potential effects of maternal mood and inflammatory disorders also need to be clarified. These findings should not discourage the use of anti-inflammatory or antidepressant medication during lactation when the use is medically indicated.