Dynamic Total-Body Imaging of Therapeutic Alpha-Emitters and their Daughters in Mice With the Alpha-SPECT-Mini-II: A Spectral-SPECT System with Total-Body/Microscopic Dual-FOV Apertures

Over the past decade, alpha-emitter radiopharmaceutical therapy (<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\alpha$</tex>-RPT) has attracted tremendous attention as a powerful cancer treatment approach in both preclinical and clinical applications. Dosimetry is the key to understanding the toxicity and efficacy profiles of αRPTs. Accurate knowledge of the distribution of the parent and daughter radionuclides is essential for precise dosimetry. For conventional radiopharmaceuticals, SPECT imaging provides a means to measure the in vivo biodistribution of radionuclides.