Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures

20251 citationsJournal Article

Authors

Jan‐Marino Ramirez · University of Washington

Margaret M. Sedensky · University of Washington

Philip G. Morgan · University of Washington

Abstract

Isoflurane causes a failure of SERCA-dependent calcium removal by inhibition of mitochondrial production of ATP. The increase in intracellular calcium leads to early signs of cellular toxicity.

Topics & Keywords

Anesthesia and Neurotoxicity Research Cardiac Ischemia and Reperfusion Mitochondrial Function and Pathology

Publication Details

Published in: Anesthesiology

Volume 144, Issue 4, pp. 871-885

DOI: 10.1097/aln.0000000000005910

Field-Weighted Citation Impact: 1.43

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Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures

Authors

Abstract

Topics & Keywords

Publication Details