Risk of Community-Acquired Pneumonia with Outpatient Proton-Pump Inhibitor Therapy: A Systematic Review and Meta-Analysis

2015322 citationsReviewgold Open Access

Authors

Allison Lambert · Johns Hopkins University

Jennifer O. Lam · Johns Hopkins University

Julie J. Paik · Johns Hopkins University

César Ugarte‐Gil · Instituto de Medicina Tropical

Michael Drummond · Johns Hopkins University

Trevor A. Crowell · Johns Hopkins University

Abstract

Outpatient PPI use is associated with a 1.5-fold increased risk of CAP, with the highest risk within the first 30 days after initiation of therapy. Providers should be aware of this risk when considering PPI use, especially in cases where alternative regimens may be available or the benefits of PPI use are uncertain.

Topics & Keywords

Pneumonia and Respiratory Infections Pneumocystis jirovecii pneumonia detection and treatment Gastroesophageal reflux and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 10, Issue 6, pp. e0128004-e0128004

DOI: 10.1371/journal.pone.0128004

Field-Weighted Citation Impact: 24.64