Patient-Specific Early Seizure Detection From Scalp Electroencephalogram

The objective of this study is to develop a method for automatic detection of seizures before or immediately after clinical onset using features derived from scalp electroencephalogram. This detection method is patient specific. It uses recurrent neural networks and a variety of input features. For each patient, we trained and optimized the detection algorithm for two cases: (1) during the period immediately preceding seizure onset and (2) during the period immediately after seizure onset. Continuous scalp electroencephalogram recordings (duration 15-62 hours, median 25 hours) from 25 patients, including a total of 86 seizures, were used in this study. Preonset detection was successful in 14 of the 25 patients. For these 14 patients, all of the testing seizures were detected before seizure onset with a median preonset time of 51 seconds and false-positive (FP) rate was 0.06/hour. Postonset detection had 100% sensitivity, 0.023/hour FP rate, and median delay of 4 seconds after onset. The unique results of this study relate to preonset detection. Our results suggest that reliable preonset seizure detection may be achievable for a significant subset of patients with epilepsy without use of invasive electrodes.