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As we embrace 2024, the field of translational medicine stands at an exciting crossroads where innovation, collaboration, and cutting-edge technology converge. Among the most powerful tools driving this transformation is preclinical imaging, a discipline that continues to redefine our ability to understand disease mechanisms and accelerate the development of effective therapies. Preclinical imaging offers an unparalleled window into the living body—enabling researchers to monitor biological processes at anatomical, cellular, and molecular levels in real time. From high-resolution micro-ultrasound and MRI to PET, SPECT, and CT, these imaging modalities are integral to visualizing disease progression, evaluating therapeutic responses, and ultimately bridging the bench-to-bedside gap in translational research. Building on the success of previous years, the TPCF (Tehran University of Medical Sciences Preclinical Core Facility) has taken a bold step forward in 2024 by expanding its flagship event into The 1st International Tehran Preclinical Imaging Conference (TPIC 2024). This evolution from symposium to conference reflects the growing impact of preclinical imaging and our community’s commitment to advancing translational science. TPIC 2024 serves as a dynamic platform for researchers, clinicians, engineers, and industry partners to exchange knowledge, present novel findings, and explore emerging imaging technologies that are shaping the future of biomedical research. With a robust scientific program, including keynote lectures, oral and poster presentations, and hands-on workshops, the conference highlights both foundational innovations and practical applications in drug discovery, disease modelling, and therapy development. We are proud that Frontiers in Biomedical Technology (FBT) continues its tradition of supporting scientific dissemination by publishing the abstracts from TPIC 2024. This compilation represents the dedication, creativity, and rigor of a global community united by a shared vision: to harness the power of imaging for better health outcomes. We invite all attendees, contributors, and readers to explore these abstracts and join us in celebrating the progress and promise of preclinical imaging. For more information about TPIC 2024, including the full program and future initiatives, please visit our website at www.TPCF.ir. Together, let us continue to illuminate the path of translational medicine—one image at a time.