Data from: Tissue-specific mutagenesis from endogenous guanine damage is suppressed by PolK and DNA repair

We report here LC-MS data using targeted adductomics and biochemical analyses to identify endogenous N2-dG lesions requiring Polk-mediated bypass, and untargeted adductomics to reveal new guanine lesions that engage NER. These findings uncover the nature of endogenous DNA damage and the coordinated roles of repair and tolerance pathways that limit mutagenesis in tissues.