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Background: Chronic non‑healing wounds impose substantial clinical and economic burdens on patients and society. Patients with multiple comorbidities and risk factors are particularly vulnerable to developing wounds with delayed healing. Advanced wound care therapy such as cellular, acellular, and matrix‑like products (CAMPs) support wound healing when conservative treatment is insufficient. Results: Case 1 (91‑year‑old female, stage IV sacral ulcer): after wound‑bed preparation and 16 CAMP applications, surface area and volume reduced by 97% and 99%, respectively. Case 2 (74‑year‑old male, stage III sacral pressure ulcer while under treatment for pneumonia): 10 CAMP applications combined with negative pressure wound therapy (NPWT) achieved 70% surface area and 93% volume reduction; the patient subsequently died of pneumonia, unrelated to the wound. Case 3 (84‑year‑old female with dementia, venous leg ulcer with fat layer exposed): seven weekly CAMP applications with compression resulted in complete closure (100% reduction in area and volume). Case 4 (75-year-old female presented with an eight-year history of a chronic, non-pressure ulcer on the lower right leg with multiple ulcerations and sickle cell disease): 5 CAMP applications over 14 weeks achieving 100% healing. Case 5 (elderly male with pressure injury on lower right extremity: 10 CAMP applications with 100% wound healing. Conclusions: This case series exemplifies how advanced therapies such as CAMP treatment, in combination with standard of care treatment and patient compliance, results in substantial wound improvement and closure. Timely access for patients to receive CAMP therapy is essential to improve healing outcomes and improve quality of life measures.