obophenotype/human-phenotype-ontology: 2025-11-24 Release

Updated Content <details> <summary>Classes added: 140</summary> | Term | ----| | Local paresthesia at bite site (HP:0020014) | | Decreased fetal head circumference (HP:0020306) | | Abnormal CSF 5-hydroxyindoleacetic acid concentration (HP:0020019) | | Irregularity of the retinal pigment epithelium layer on OCT (HP:0020033) | | Abnormal fetal head circumference (HP:0020305) | | Squamous metaplasia (HP:0020094) | | Subcutaneous abscess (HP:0020116) | | Hallux dorsiflexion weakness (HP:6001374) | | Cystic changes in greater tuberosity of the humerus (HP:6001371) | | Positive Hawkins test (HP:6001372) | | Hip extension contracture (HP:0020024) | | Elevated circulating lysosphingomyelin concentration (HP:6001380) | | Elbow instability (HP:6001426) | | Abnormal fetal femur length (HP:6001418) | | Necrotizing lymph node granuloma (HP:0020052) | | Lateral epicondylitis of the elbow (HP:6001364) | | Amyloid deposition by type of amyloid (HP:0020016) | | Diminished MLH1 expression (HP:0020055) | | Distal biceps tendon ruptre (HP:6001367) | | Pain exacerbated by wrist radial deviation (HP:6001420) | | Direct antiglobulin test positive for IgG (HP:0020027) | | Hallux pain (HP:6001401) | | Negative ulnar variance (HP:6001422) | | Hip adduction contracture (HP:0020023) | | Pathological inclusion body by subcellular location (HP:0020066) | | Valgus instability of the elbow (HP:6001427) | | History of disease onset in winter (HP:0020008) | | Increased fetal head circumference (HP:0020307) | | Echopraxia (HP:0020124) | | Diminished MSH2 expression (HP:0020056) | | Limited foot inversion (HP:6001430) | | Abnormal lens capsule morphology (HP:6001381) | | Pain exacerbated by wrist ulnar deviation (HP:6001419) | | Abnormal elbow morphology (HP:0020300) | | Abnormal anteroposterior retina thickness on OCT (HP:0020040) | | Diminished MSH6 expression (HP:0020057) | | Hip flexion contracture (HP:0020025) | | Skin tenting due to fracture (HP:6001384) | | Areas of hypopigmentation and hyperpigmentation that follow Blaschko lines (HP:6001387) | | Restrictive eating (HP:0020302) | | Flat palate (HP:6001411) | | Posterior tibial tendon injury (HP:6001398) | | Bleeding into skin lesions (HP:0020011) | | Urinary ascites (HP:6001378) | | Granulomatous conjunctivitis (HP:6001386) | | Hyperlordotic gait (HP:6001360) | | Volar wrist pain (HP:6001405) | | Transthyretin amyloid deposition (HP:0020017) | | Transillumination test shows high light transmission (HP:6001424) | | Spilled teacup sign of the wrist (HP:6001395) | | Abnormal Q wave (HP:0020232) | | Tumor signet ring cell (HP:0020168) | | Abnormal spinal cord white matter morphology (HP:0020029) | | Distal radioulnar joint space widening (HP:5000040) | | Positive Coombs test (HP:0020026) | | Acute retinal necrosis (HP:6001370) | | Hyperleukocytosis (HP:6001425) | | Abnormal mixed venous oxygen saturation (HP:6001379) | | Fleck sign of elbow (HP:6001362) | | Ulnar positive variance (HP:6001421) | | Slough (HP:0020013) | | Popeye sign (HP:6001366) | | Peroneal tendon tenderness (HP:6001407) | | Retinal thickening on OCT (HP:0020039) | | Decreased biparietal diameter (HP:0020259) | | Hallux sesamoid injury (HP:6001403) | | Varus instability of the elbow (HP:6001428) | | Abnormal spinal cord lateral corticospinal tract morphology (HP:0020030) | | Direct antiglobulin test positive for C3d (HP:0020031) | | Increased occipitofrontal diameter (HP:0020299) | | Positive Finkelstein sign (HP:6001396) | | Increased biparietal diameter (HP:0020260) | | Decreased occipitofrontal diameter (HP:0020298) | | Crusted skin lesions (HP:0020012) | | Appendicular location (HP:0020069) | | Elevated bursal fluid leukocyte count (HP:0020256) | | Positive synovial Tropheryma whipplei bacteria microscopy (HP:6001431) | | Hallux plantarflexion weakness (HP:6001375) | | Cutaneous lesion morphology (HP:0020010) | | Exacerbated by pulmonary vasodilator exposure (HP:6001413) | | Elevated circulating C-terminal telopeptide cross-link of type1 collagen concentration (HP:6001412) | | Plantar pain (HP:6001399) | | Distal radioulnar joint translation (HP:5000049) | | Pathological inclusion body by anatomical location (HP:0020067) | | Dorsal intercalated segment instability (HP:6001393) | | Hallux weakness (HP:6001373) | | Spur at inferior pole of patella (HP:6001377) | | Increased fetal abdominal circumference (HP:0020304) | | Cerebral transthyretin amyloid deposition (HP:0020018) | | Bronchial stenosis (HP:6001383) | | Proximal biceps tendon rupture (HP:6001368) | | Flexor carpi radialis tendonitis (HP:6001423) | | Follicular conjunctivitis (HP:6001385) | | Forefoot pain (HP:6001376) | | Abnormal seminiferous tubule morphology (HP:0020051) | | Peroneal tendon injury (HP:6001409) | | Achilles tendon tear (HP:6001433) | | Intrauterine amputation (HP:6001389) | | Abnormal occipitofrontal diameter (HP:0020297) | | Dorsal wrist pain (HP:6001406) | | Intrauterine digital amputation (HP:6001390) | | Radial wrist pain (HP:6001404) | | Mercury exposure (HP:6001414) | | Disruption of carpal arcs (HP:6001394) | | Proximal interphalangeal joint arthritis (HP:6001392) | | Abnormal CD8+ T cell subset proportion (HP:0020115) | | Hip external rotation contracture (HP:0020021) | | Decreased CSF 5-hydroxyindoleacetic acid concentration (HP:0020020) | | Elevated circulating succinylacetone concentration (HP:6001410) | | Radioulnar interosseous membrane tear (HP:6001361) | | Direct antiglobulin test positive for IgM (HP:0020028) | | Abnormal bursal fluid morphology (HP:0020252) | | Abnormal marker expression (HP:0020053) | | Diminished PMS2 expression (HP:0020065) | | Peroneal tendon subluxation (HP:6001408) | | Hip abduction contracture (HP:0020022) | | Medial epicondylitis of the elbow (HP:6001365) | | Limited foot eversion (HP:6001429) | | Histopathological abnormality (HP:0020092) | | Abnormal biparietal diameter (HP:6001417) | | History of disease onset in summer (HP:0020009) | | Forefoot abduction (HP:6001397) | | Abnormal neoplastic cell morphology (HP:0020162) | | Pain on the medial aspect of the foot (HP:6001402) | | Hyperreflective retinal dots on OCT (HP:0020032) | | Positive bursal fluid infectious agent test (HP:6001369) | | Amyloid deposition by anatomical site (HP:0020015) | | Glomerular basement membrane duplication (HP:0020109) | | Urinoma (HP:6001415) | | Resisted wrist flexion provokes pain (HP:6001363) | | Abnormal elbow physiology (HP:0020301) | | Flexor hallucis longus tendon injury (HP:6001400) | | Abnormal fetal abdominal circumference (HP:0020303) | | Umbilical discharge (HP:6001416) | | Exposure to humid conditions (HP:0020070) | | Intranuclear inclusion bodies (HP:0020068) | | Retinal drusen (HP:6001388) | | Posterior capsule opacification (HP:6001382) | | Positive calf squeeze test (HP:6001432) | | Intrauterine limb amputation (HP:6001391) | </details> <details> <summary>Nodes renamed: 34</summary> | ID | Old Label | New Label | ----|----|----| | HP:0004298 | Abnormality of the abdominal wall | Abnormal abdominal wall morphology | | HP:6000339 | Small fetal abdominal circumference | Decreased fetal abdominal circumference | | HP:0008715 | Testicular dysgenesis | obsolete Testicular dysgenesis | | HP:0030220 | Socially inappropriate behavior | obsolete Socially inappropriate behavior | | HP:0030329 | Retinal thinning | Retinal thinning on OCT | | HP:0031349 | Levotransposition of the great arteries | obsolete Levotransposition of the great arteries | | HP:0009189 | Fragmentation of the metacarpal epiphyses | Fragmented metacarpal epiphysis | | HP:5200136 | Reduced social reciprocity with peers | Reduced social reciprocity | | HP:6001359 | Subcutaneous abscess | Cholesterol gallblader polyp | | HP:0003133 | Abnormality of the spinocerebellar tracts | Abnormal spinocerebellar tract morphology | | HP:0005109 | Abnormality of the Achilles tendon | Abnormal Achilles tendon morphology | | HP:0040103 | Cutaneous stenosis of the external auditory canal | Acquired stenosis of the external ear canal | | HP:0030050 | Narcolepsy | obsolete Narcolepsy | | HP:0100786 | Hypersomnia | obsolete Hypersomnia | | HP:0031297 | Unroofed coronary sinus | obsolete Coronary sinus atrial septal defect | | HP:0003999 | Abnormality of radial epiphyses | Abnormal radial epiphysis morphology | | HP:0041219 | Fractured elbow | Elbow fracture | | HP:0000728 | Impaired ability to form peer relationships | Reduced ability to form peer relationships | | HP:0010596 | Abnormality of the proximal radial epiphysis | Abnormal proximal radial epiphysis morphology | | HP:0010599 | Abnormality of the distal humeral epiphysis | Abnormal distal humeral epiphysis morphology | | HP:0003946 | Abnormality of the epiphyses of the elbow | Abnormal elbow epiphysis morphology | | HP:0012509 | Reduced thyroxin-binding globulin | obsolete Reduced thyroxin-binding globulin | | HP:0009881 | Aplasia of the distal phalanges of the hand | Aplasia of distal finger phalanx | | HP:0031327 | Transthyretin cardiac amyloidosis | Cardiac transthyretin amyloid deposition | | HP:0005807 | Absent distal phalanges | obsolete Absent distal finger phalanx | | HP:0011540 | Congenitally corrected transposition of the great arteries | Levotransposition of the great arteries | | HP:0001152 | Saccadic smooth pursuit | Saccadic smooth pursuit interruptions | | HP:0008733 | Dysplastic testes | Dysplastic testis | | HP:0008311 | Spinal cord posterior columns myelin loss | Spinal cord dorsal column hypomyelination | | HP:0002438 | Cerebellar malformation | obsolete Cerebellar malformation | | HP:0003841 | Fragmented epiphyses of the upper limbs | Fragmented upper limb epiphysis | | HP:0011397 | Abnormality of the dorsal column of the spinal cord | Abnormal spinal cord dorsal column morphology | | HP:0010232 | Fragmentation of the epiphyses of the phalanges of the hand | Fragmented finger phalanx epiphysis | | HP:0011034 | Amyloidosis | Amyloid deposition | </details> <details> <summary>Nodes o