Abstract 13: Primary Ovarian Cancer in Patients Under 30 Years Old in Guatemala: A Retrospective Comparative Cohort Study

Abstract Purpose: Globally ovarian cancer is the eighth most common women’s cancer in 2020 and the deathliest cancer affecting women’s health due to lack of effective early detection methods for identifying ovarian cancer which has a link to family history for breast and ovarian cancer, however, survival rates are significantly higher when the disease is detected at early stages; therefore, the aim of this study is to evaluate clinicopathological characteristics of younger patients < and ≥30 years of age with primary ovarian cancer. Methods: A retrospective cohort study reviewed the medical and pathological records from 2010–2019 of women patients ≥18 years diagnosed with primary ovarian cancer at the Liga Nacional Contra el Cáncer e INCAN, the only specialized multidisciplinary oncologic hospital in Guatemala. Staged cases were the inclusion criteria, continuous data are presented as median and interquartile range (IQR), categorical data as frequency and percentage. Subjects were categorized into two groups, younger group (<30 years) and older group (≥30 years). Statistical analyses were performed with Chi-squared, Fisher’s exact test, and Kruskal-Wallis test. Results: Among 414 women patients, 24.4% were <30 and 75.6% ≥30 years old. The median (IQR) age of patients in the younger group were 22(19–26) in comparison to the older group 52(45–56) years old respectively, p<0.0001, patients in ovarian cancer stages ≥II were 62.87% in under 30 compared to 77.9% in the older group respectively (p=0.038). In the younger group 76(75.24%) compared to 216(69.1%) in the older group underwent surgery alone or combined with chemotherapy, respectively, p=0.081. Patients with epithelial ovarian cancer were 26.73% in the younger group compared to 92.33% in older group respectively, non-epithelial ovarian cancer was present in 73.27% compared to 7.67% in the older group respectively, p=0.000. Conclusion: Women with family history of breast and ovarian cancer should be closely monitored with timely tests such as ultrasound and tumor markers such as α-fetoprotein, β-hCG, CA-125 blood test (according to age) among others, providing them the opportunity to implement ovarian cancer detection strategies, a potential approach nation-wide in women at risk. Citation Format: Angel Velarde López, Alberto García, Javier Figueroa, Isabel Orozco, Milton Ixquiac, Roilan Gomez, Vicky De Falla, Hiram Gay. Primary Ovarian Cancer in Patients Under 30 Years Old in Guatemala: A Retrospective Comparative Cohort Study [abstract]. In: Proceedings of the 13th Annual Symposium on Global Cancer Research; 2025 Sep 16. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(12_Suppl):Abstract nr 13.