σH-Adducts of 2-R-6-Nitro-1,2,4-triazolo[1,5-a]pyrimidines Containing a 2,5-Disubstituted Tetrazole Fragment in the Molecule

20250 citationsJournal Article

Authors

E. B. Gorbunov · Ural Branch of the Russian Academy of Sciences

R. I. Ishmetova · Institute of Organic Synthesis

A. A. Tumashov · Institute of Organic Synthesis

N. A. Gerasimova · Ural Institute of Cardiology

N. P. Evstigneeva · Ural Scientific Research Institute of Dermatovenerology and Immunopathology

G. L. Rusinov · Institute of Organic Synthesis

Abstract

A method for the direct introduction of 2-(R-phenacyl)methyl-5-aryl(heteryl)tetrazole fragments into the molecule of 2-R-6-nitro-1,2,4-triazolo[1,5-a]pyrimidines via a nucleophilic addition reaction has been developed. The antimicrobial activity of some synthesized compounds was evaluated against the reference strain Neisseria gonorrhoeae ATCC 49226/NCTC 12700 and museum strains of dermatophyte and yeast-like fungi.

Topics & Keywords

Synthesis of Tetrazole Derivatives Synthesis and biological activity Synthesis and Reactivity of Heterocycles

Publication Details

Published in: Russian Journal of General Chemistry

Volume 95, Issue 11, pp. 3556-3562

DOI: 10.1134/s1070363225605927

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σH-Adducts of 2-R-6-Nitro-1,2,4-triazolo[1,5-a]pyrimidines Containing a 2,5-Disubstituted Tetrazole Fragment in the Molecule

Authors

Abstract

Topics & Keywords

Publication Details