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This dataset contains all data and materials necessary to reproduce the results presented in the article "PANORAMA: A robust pangenome-based method for predicting and comparing biological systems across species" by Jérôme Arnoux, Jean Mainguy, Laura Bry, Quentin Fernandez de Grado, Yazid Hoblos, DavidVallenet & Alexandra Calteau. The article introduces PANORAMA, a bioinformatics tool for predicting and comparing biological systems from pangenomes. The dataset includes: Input data: Pangenome files used as input for the analyses Output data: Complete results generated by PANORAMA as presented in the manuscript Genome list: Catalog of genomes used to construct the pangenomes Python script: to generate figures presented via Google Colab All data and results can be used to fully reproduce the analyses and figures presented in the publication. Contents: pangenomes.tar.xz/ - Pangenome input files DATA.tar.xz/ - Results generated by PANORAMA & source script to generate figures Genomes.tar.xz - List of genomes used for pangenomes construction