Behind the Itch: Mapping the Interplay Between Genetics, Immunity, and Lifestyle in Skin Irritation with Rash

Eczema, or atopic dermatitis, affects nearly 10% of adults worldwide and imposes a heavy burden through chronic itch and impaired quality of life. While many genetic, immune, and lifestyle factors have been proposed, their relative contributions and interactions remain unclear, particularly across different age groups. To address this gap, we designed a survey-based study that systematically investigated demographic, behavioral, and environmental contributions to eczema among teenagers and adults. Survey items were developed based on an extensive literature review and targeted factors such as age, gender, stress, sleep, moisturization, and public awareness of skin conditions. Responses were analyzed using statistical method to identify significant associations and exclude spurious correlations, Among the numerous factors examined, age, gender, and moisturization habits consistently emerged as significant predictors of eczema. These findings refine our understanding of the condition by emphasizing significant correlates and clarifying misconceptions surrounding eczema. By distinguishing between meaningful associations and less relevant factors, this research contributes both to the scientific knowledge of eczema and to public health practice in managing one of the worlds most common skin conditions.