142 An observational, cross-sectional study evaluating the humanistic and economic burden of migraine with comorbid depression

a:2:{s:4:"lang";s:2:"en";s:7:"content";s:1533:"<h3>Objective</h3> To evaluate the humanistic and economic burden of migraine with versus without comorbid depression in European countries, South Korea and Brazil. <h3>Methods</h3> This observational, cross-sectional study included respondents of the 2020 (South Korea and Brazil) and 2022 (France, Germany, Italy, Spain, United Kingdom) National Health and Wellness Survey who self-reported physician-diagnosed migraine for ≥12 months, had active migraine for ≤12 months, and ≥4 headache days in the preceding month, with or without depression. Outcomes included migraine-related disability (MIDAS), health-related quality of life (EQ-5D Index) and total costs. <h3>Results</h3> Among respondents in Europe (N=1073), Brazil (N=331) and South Korea (N=219), 35.7%, 32.9% and 36.5% had depression, respectively. Across all regions, respondents with versus without depression had a greater number of migraines in the past 30 days (mean: Europe, 7.2 vs 5.0; p&lt;0.001; Brazil, 9.2 vs 6.5; p&lt;0.001; South Korea, 8.7 vs 6.1, p=0.004); and greater disability (MIDAS score ≥20: Europe, 60.8% vs 30.1%; Brazil, 65.1% vs 35.6%; South Korea, 48.8% vs. 20.9%; all p&lt;0.001). Respondents with versus without depression had lower EQ-5D Index scores (all p&lt;0.001); and higher direct and indirect costs (all p&lt;0.001). <h3>Conclusion</h3> People with migraine and active depression experience higher humanistic and economic burden compared with those without depression. mark.fredericks{at}tevauk.com ";}