Spontaneous Bacterial Peritonitis Is Associated With High Mortality, Which Interacts With Antibiotic Prophylaxis in a National Cirrhosis Cohort

In a national cohort of newly decompensated cirrhosis Veterans, SBP increased mortality, which worsened with recurrence. SBP prophylaxis (primary or secondary) showed an interaction with higher mortality but not LT. Antibiotic resistance increased with SBPPr, but culture results were not followed while resuming/initiating SBPPr. Novel strategies to prevent SBP recurrence and mortality are needed.