Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models

20250 citationsJournal Articlegold Open Access

Authors

Yusuke Tomita · Northwestern University

Gabrielle Link · Morgan Adams Foundation

Yi Ge · Mount Sinai Health System

Emma R. H. Gold · Mount Sinai Health System

Anna Racanelli · Mount Sinai Health System

Herminio Joey Cardona · Northwestern University

Megan M. Romero ·

Abstract

Combination therapy with ribociclib and trametinib significantly prolonged survival in the GEM model but not in the PDX model, highlighting the importance of testing novel therapies in diverse models.

Topics & Keywords

Advanced Breast Cancer Therapies Glioma Diagnosis and Treatment Brain Metastases and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 20, Issue 12, pp. e0323235-e0323235

DOI: 10.1371/journal.pone.0323235

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