Amyloid Degradation Toxicity Hypothesis: the framework that explains multiple phenomena and paradoxes associated with Alzheimer’s disease

Amyloid Degradation Toxicity Hypothesis is a conceptual framework that is open to developing and changing over time based on new findings relevant to the AD etiology. We expect that the testing of follow-up hypotheses, which can be formulated based on this framework, will extend our understanding of AD. Notably, the theory suggests new AD-pathobiology-relevant biomarkers and novel, previously untested molecular targets for creating pharmacological agents to prevent or slow down the progression of this devastating neurodegenerative disease.