One Size Does Not Fit All: Menopause Hormone Therapy Type and Route of Administration Influences Cognitive Health

These results underscore the differential effects of E2- and E1-based MHT depending on route of administration and cognitive domain tested. Notably, these results may reflect dose-dependent effects of estrogens; episodic memory may benefit from greater ER activation than prospective memory. This work clarifies the mixed MHT literature and may inform emerging precision medicine approaches for cognitive aging in females.