COVID‐19 and Cognitive Decline: AI‐Driven Insights into Risk Detection Among Older Adults using All of Us Dataset

COVID-19 appears to be a significant driver of cognitive impairment in older adults, particularly among individuals with specific comorbid profiles. Our findings reinforce the importance of integrating infection history, comorbidities, and individual background factors into models of cognitive decline risk. This study supports the development of explainable AI tools that model varied cognitive trajectories and inform individualized intervention planning across a range of patient profiles. Future work will focus on refining these models for clinical integration and validating their utility in prospective real-world settings.