Hippocampal vascularization is associated with greater efficiency during a remote real world wayfinding training in older adults

We provide evidence that a remotely administered real-world wayfinding training enhances wayfinding abilities and improves spatial memory in older adults. Importantly, hippocampal vascularization may benefit wayfinding efficiency. Higher pTau217 was related to fewer orientation stops during navigation. As a next step, potential mediating effects between vascularization and AD pathology on wayfinding performance will be investigated.