Differential Vascular and Non‐Vascular Binding Patterns of ACU193 and R‐Lecanemab in APP;hAPOE4 Mouse Brain Sections

ACU193 and r-lecanemab differ in their concentration-dependent binding, labeling of non-vascular and vascular Aβ, fibrillar selectivity and regional patterns. Fixation time influenced antibody binding, particularly non-vascular staining. Double-label analyses with markers of Aβ, vasculature, neurons, and dystrophic neurites are underway to provide further insight into the localization of antibody binding. Funding_1R01NS136122-01_CAL.