White matter perivascular spaces are associated with lower phosphorylated tau and preserved cognitive function in Alzheimer’s Disease

These findings suggest that enlarged WM PVS are associated with lower peripheral pTau217 levels, which may contribute to preserved cognitive function in AD patients, but not in CVD patients. Understanding how PVS dynamics differ across neurodegenerative diseases could provide insight into their distinct origins and clinical consequences, guiding the development of targeted therapies.