YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility

20250 citationsJournal Articlehybrid Open Access

Authors

Tara Fresques · University of the Pacific

Jennifer C. Lopez · City of Hope

Deborah Hussey · City of Hope

Masaru Miyano · City of Hope

James C. Garbe · Lawrence Berkeley National Laboratory

Stefan Hinz · City of Hope

Rosalyn W. Sayaman ·

Abstract

Dysregulated YAP1 occurs with aging in mammary epithelial cells, leading to molecular changes associated with stem cell states and increased growth potential. YAP1 may act before tumor development to induce cancer-susceptible molecular states.

Topics & Keywords

Hippo pathway signaling and YAP/TAZ Cancer Cells and Metastasis Telomeres, Telomerase, and Senescence

Publication Details

Published in: Cancer Prevention Research

Volume 19, Issue 4, pp. 203-218

DOI: 10.1158/1940-6207.capr-25-0027

Field-Weighted Citation Impact: 0.00

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YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility

Authors

Abstract

Topics & Keywords

Publication Details