Machine Learning–Enhanced Prognostic Modeling in Elderly Glioblastoma Isocitrate Dehydrogenase-Wildtype: A Multidimensional Single-Center Cohort Study

This study confirmed prognostic relevance of GTR, O6-methylguanine-DNA methyltransferase methylation, and RT + TMZ combination. Baseline Karnofsky Performance Status and age did not demonstrate independent prognostic value, while BMI and cognitive decline were potential preoperative predictors. Our findings advocate a multidimensional, data-driven approach to preoperative risk stratification in elderly GBM patients, which may facilitate individualized treatment strategies.