Neuron‐Derived Extracellular Vesicles as a Blood‐Based Biomarker for Alpha‐Synuclein Across Synucleinopathies

20250 citationsJournal Articlehybrid Open Access

Authors

Erez Eitan · NeuroBioTex (United States)

Dina Ayupova · NeuroBioTex (United States)

Olga V. Volpert · NeuroBioTex (United States)

Alexander Gekas · NeuroBioTex (United States)

Abstract

NDE-associated aSyn is significantly elevated in synucleinopathy patients across multiple cohorts, supporting its potential as a blood-based biomarker. Further work is needed to standardize preanalytical conditions, establish a unified diagnostic threshold, and evaluate assay sensitivity at the individual level for clinical application.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Extracellular vesicles in disease Amyotrophic Lateral Sclerosis Research

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue S8, pp. e110157-e110157

DOI: 10.1002/alz70862_110157

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Neuron‐Derived Extracellular Vesicles as a Blood‐Based Biomarker for Alpha‐Synuclein Across Synucleinopathies

Authors

Abstract

Topics & Keywords

Publication Details