A New Amyloid‐Beta and Tau Co‐Pathology Mouse Model of Alzheimer’s Disease

This novel APP/PS1/hTau mouse model reproduces key Alzheimer's disease features, including parenchymal and vascular amyloid-β deposits, phosphorylated tau, microgliosis, astrogliosis, and sleep disturbances. It also exhibits a clear neurodegenerative phenotype with regional brain atrophy detectable by MRI, offering translational relevance. The model enables investigation of proteinopathy-neuroinflammation interactions and provides quantifiable in-life and post-mortem endpoints, making it a valuable tool for preclinical testing of disease-modifying therapies in Alzheimer's disease.