A case of gastric polyps with dysplasia that could not be detected after the two months of discontinuation of rabeprazole

An 85-year-old woman with over 10 years of rabeprazole use developed multiple gastric fundic gland polyps. The largest polyp in great curvature enlarged from 10 mm to 20 mm over one year. Histopathological assessment of the polyp revealed low grade dysplasia, and endoscopic submucosal dissection was planned. However, the polyp with dysplasia could not be detected after the two months of discontinuation of rabeprazole and only the biopsy scar existed. Biopsy of the scar showed no dysplasia. This case suggests careful consideration of timing between PPI cessation and endoscopic intervention when planning diagnostic treatment of PPI-related fundic gland polyps.