Characterization of the APP <sup>SAA</sup> mouse model for use in preclinical testing of Alzheimer's disease therapeutics

20250 citationsJournal Articlehybrid Open Access

Authors

Michael Sasner · Jackson Laboratory

Dylan Garceau · Jackson Laboratory

Nick Ryan · Jackson Laboratory

Ritesh Chidambaram · TissueVision (United States)

T. Ragan · TissueVision (United States)

Asli Uyar · Jackson Laboratory

Ravi S. Pandey ·

Abstract

The APP<sup>SAA</sup> model is a more translationally relevant model than transgenic overexpression models for studying early onset amyloidosis and microglial activation, and is available without legal restrictions. Here we demonstrate key assays and appropriate ages/disease stages for preclinical testing.

Topics & Keywords

Alzheimer's disease research and treatments Single-cell and spatial transcriptomics Neuroinflammation and Neurodegeneration Mechanisms

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue S1, pp. e105192-e105192

DOI: 10.1002/alz70855_105192

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Characterization of the APP <sup>SAA</sup> mouse model for use in preclinical testing of Alzheimer's disease therapeutics

Authors

Abstract

Topics & Keywords

Publication Details