IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccine

20250 citationsJournal Articlegold Open Access

Authors

Tanisha M. Robinson · Walter Reed Army Institute of Research

Jessica S. Bolton · Walter Reed Army Institute of Research

Elisabeth H. Duncan · Walter Reed Army Institute of Research

Elke Bergmann-Leitner · Walter Reed Army Institute of Research

Marie Mura · HIA du Val-de-Grâce à Paris

Abstract

Controlled human malaria infections after immunization via mosquito bites with radiation attenuated Plasmodium falciparum sporozoites are necessary tools to decipher immune signatures of malaria protection. The phenotype of circulating mononuclear innate cells and the PBMC response to in vitro stimulation unraveled correlates of protection from baseline immune response to sporozoite stimulation (IFN-ƴ secretion and HLA-DR<sup>high</sup> expression) to vaccine-induced immune factors (IL-4 secretion and CD57<sup>-</sup> γδ T cell frequency).

Topics & Keywords

Malaria Research and Control Invertebrate Immune Response Mechanisms T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: npj Vaccines

Volume 10, Issue 1, pp. 268-268

DOI: 10.1038/s41541-025-01308-5

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