MTHFR 1298C and 677T Interactions with APOE e4 and White Matter Hyperintensity Volume on Amyloid‐Positive Status in Cognitively Unimpaired Older Adults

CU individuals who carry the APOE e4 and 677T allele of MTHFR are more likely to be classified as amyloid-positive. Treatments that target vascular-related APOE e4 and MTHFR 677T pathways may help ameliorate downstream amyloid pathology in AD.