Longitudinal T-Cell Phenotypic Dynamics During Sustained Antiretroviral Therapy in People With HIV

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Authors

Christophe Guy Éric Vanpouille · Eunice Kennedy Shriver National Institute of Child Health and Human Development

A. F. Wells · University of California San Diego

Victor DeGruttola · Human Longevity (United States)

Miranda L. Lynch · University at Buffalo, State University of New York

Xinlian Zhang · University of California San Diego

Xin Tu · University of California San Diego

Abstract

Long-term ART promotes partial immune normalization, including reduced activation and reversal of CD4⁺ T-cell exhaustion. However, persistent expression of CD8⁺ T-cell surrogate markers of exhaustion and stable cytotoxic profiles suggest ongoing antigenic stimulation, potentially driven by HIV or chronic coinfections.

Topics & Keywords

HIV Research and Treatment HIV/AIDS drug development and treatment HIV/AIDS Research and Interventions

Publication Details

Published in: Open Forum Infectious Diseases

Volume 13, Issue 1, pp. ofaf775-ofaf775

DOI: 10.1093/ofid/ofaf775

Field-Weighted Citation Impact: 0.00

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Longitudinal T-Cell Phenotypic Dynamics During Sustained Antiretroviral Therapy in People With HIV

Authors

Abstract

Topics & Keywords

Publication Details