PLD3 contributions to vascular dysfunction in the context of AD

Our findings demonstrate that PLD3 influences vascular function and inflammation in mice, potentially contributing to disease pathogenesis. In iPSC-derived vascular models, PLD3 regulates EC proliferation and APP processing as well as mural cell matrix organization, suggesting that this variant may lead to vascular remodeling or instability. Future studies will explore the underlying mechanisms of these alterations and assess whether they can be targeted to prevent vascular dysfunction.