Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation

Dutch oAβ accumulation associates with aging-related defects in learning behavior, presynaptic function & mitochondrial structure & function. Brain PET imaging with Lys(64Cu /NOTA)]-CP may enable development of an assay for monitoring oAβ levels & distribution for diagnosing living human subjects & patients.