Grabody B, an IGF1R‐targeting Molecular Shuttle, Sustains Brain Penetration of Therapeutic Antibody in Aged Mice by Multiple, Novel Transcytosis Pathways

We confirm that Grabody B improves brain penetration of therapeutics with avoidance of the BCSFB-related routes. Grabody B utilizes multiple transcytosis pathways including Clathrin, caveolin, and FEME, which enables sustained brain penetration in aged rodents.