A difference that matters: the aortic root anatomy of large animal models vs. humans

20250 citationsJournal Articlegold Open Access

Authors

Venessa Strauss · Access Technologies

Harish Appa · Access Technologies

P. Human · University of Cape Town

Ferdinand Vogt · Paracelsus Medizinische Privatuniversität

Waled Hadasha · Access Technologies

Jacques Scherman · University of Cape Town

Q. M. S. H. Said-Hartley ·

Abstract

Validation of <i>ex vivo</i> silicone casting against <i>in vivo</i> CT confirmed its suitability for scalable anatomical assessment while aligning with animal welfare principles. These findings support refinement of animal selection strategies and provide an anatomically grounded framework for preclinical evaluation of transcatheter valve technologies.

Topics & Keywords

Cardiac Valve Diseases and Treatments Aortic Disease and Treatment Approaches Congenital Heart Disease Studies

Publication Details

Published in: Frontiers in Cardiovascular Medicine

Volume 12, pp. 1699721-1699721

DOI: 10.3389/fcvm.2025.1699721

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A difference that matters: the aortic root anatomy of large animal models vs. humans

Authors

Abstract

Topics & Keywords

Publication Details