Utility of Plasma pTau217 and NF‐L in Predicting β‐Amyloid Status: Findings from a Multicenter Study in Catalonia

Plasma pTau217 showed high AD diagnostic accuracy, and may reduce the need for other procedures like CSF/PET. The use of two diagnostic thresholds appears optimal, with 26% of subjects in intermediate ranges, potentially indicating early AD changes. NF-L were elevated in neurodegeneration but showed limited clinical utility in our study. This study supports the use of pTau217 in clinical practice, promoting diagnostic uniformity across Catalonia.