Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology

20250 citationsJournal Articlehybrid Open Access

Authors

Mario Tranfa · Amsterdam University Medical Centers

Leonard Pieperhoff · Amsterdam University Medical Centers

G. Pontillo · Federico II University Hospital

Emma S. Luckett · Amsterdam University Medical Centers

Lyduine E. Collij · Lund University

Tiago Gil Oliveira · University of Minho

Niccoló Tesi

Abstract

Polygenic risk for AD influences WM integrity both directly and via AD pathology-dependent effects. Genetic susceptibility to preclinical AD pathology activates distinct biological processes that differentially affect WM integrity.

Topics & Keywords

Advanced Neuroimaging Techniques and Applications Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue S2, pp. e098970-e098970

DOI: 10.1002/alz70856_098970

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Polygenic pathways shape white matter vulnerability to Alzheimer's disease pathology

Authors

Abstract

Topics & Keywords

Publication Details