Integrative cross‐omics analysis identifies DNA methylation signatures associated with bilateral hippocampal volume, asymmetry and atrophy rate in the general population

20250 citationsJournal Articlehybrid Open Access

Authors

Dan Liu · German Center for Neurodegenerative Diseases

Valentina Talevi · German Center for Neurodegenerative Diseases

Juliana F. Tavares · German Center for Neurodegenerative Diseases

Ruiqi Wang

Mohammed Aslam Imtiaz · German Center for Neurodegenerative Diseases

Konstantinos Melas · German Center for Neurodegenerative Diseases

Alexander Teumer · Universitätsmedizin Greifswald

Abstract

Our findings reveal methylation signatures as potential biomarkers or therapeutic targets for age- or neurodegeneration-related hippocampal atrophy. They further underscore the influence of modifiable dietary patterns on methylation and hippocampal health.

Topics & Keywords

Epigenetics and DNA Methylation Neurogenesis and neuroplasticity mechanisms Alzheimer's disease research and treatments

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue S2, pp. e099862-e099862

DOI: 10.1002/alz70856_099862

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Integrative cross‐omics analysis identifies DNA methylation signatures associated with bilateral hippocampal volume, asymmetry and atrophy rate in the general population

Authors

Abstract

Topics & Keywords

Publication Details