Amniotic fluid stem cell-conditioned media as a therapeutic adjunct in peripheral nerve injury repair: insights from a sciatic nerve mouse model

AFS-CM shows promise as a therapeutic adjunct in peripheral nerve repair, improving functional outcomes and reducing muscle atrophy compared to hydrogel-only reconstruction. While electrophysiological and morphological outcomes showed no significant differences, the enhanced gait performance and NMJ recovery observed in the AFS-CM group highlight its regenerative potential. Further studies are warranted to elucidate the underlying mechanisms and to optimize the clinical application of AFS-CM in peripheral nerve injury management.