Sex Differences in the role of Additive Genetic Variants in Autism: A Systematic Review

Findings suggest an axis of heterogeneity around intellectual disability. Inconsistent findings largely resulted in inconclusive evidence. Results highlight a lack of sex-stratified reporting and were limited by sample makeup such as male- and European ancestry dominated cohorts. Future sex-balanced and stratified GWAS and downstream analyses with complete reporting of female and male data are needed to clarify potential genetic sex differences in autism.