Long-Term Safety and Efficacy of Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid to Improve Skin Laxity of the Inner Upper Arms: A Single-Arm Study

In a single-center study conducted over a 12-month study period, we investigated the long-term safety and efficacy of Profilo Body® (IBSA Farmaceutici Italia Srl, Lodi, Italy) for treating upper inner arm skin laxity. The study participants included women (37-65 years) with at least initial signs of skin laxity and roughness on their upper arms. The treatment consisted of two injections of Profhilo Body® one month apart, followed by five injections two months apart, and a follow-up evaluation one month later. We assessed the study participants using the IBSA Photographic Scale for Assessment of Upper Inner Arm Skin Laxity. At the end of the study, the participants also completed a self-evaluation questionnaire related to product efficacy and tolerability. A total of 34 enrolled participants received the first three injections. A total of 32 participants received the next four injections. We found that slight ecchymosis occurred in 36 participants. The results of the study showed a significant decrease in median IBSA Photographic Scale for Assessment of Upper Inner Arm Skin Laxity scores at Month 3 compared with baseline scores (p < .0001). This decrease was maintained through Month 12. At least 50% of the participants experienced a moderate improvement in skin firmness, smoothness, brightness, hydration, and overall inner arm appearance that continued through Month 12. The participants self-evaluated tolerability of the product as "optimal." Based on the results of this study, we conclude that long-term use of Profhilo® Body is safe and effective for reducing skin laxity of the upper inner arms.