Nef HIV-1 (<i>Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1</i>), multifunctional protein: features of genetic virus variants circulating in Russia

The differences in Nef sequences of HIV-1 variants circulating in Russia could affect the functional properties of the protein and could be taken into account in creating Nef-based therapies in the future. Obtained results indicate that there is no risk of resistance to dolutegravir associated with - mutations in the Nef protein. It outlines possible directions for further research into the genetic diversity of Nef.